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Important Safety Information

Who should not take Neulasta®?

Do not take Neulasta® if you have had a serious allergic reaction to pegfilgrastim (Neulasta®) or to filgrastim (Neupogen®).

What should I tell my health care provider before taking Neulasta®? Tell your healthcare provider if you:

  • Have sickle cell trait or sickle cell disease
  • Have had severe skin reactions to acrylic adhesives
  • Are allergic to latex
  • Have any other medical problems
  • Are pregnant or plan to become pregnant
  • Are breastfeeding or plan to breastfeed

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are possible serious side effects of Neulasta®?

  • Spleen Rupture. Your spleen may become enlarged and can rupture while taking Neulasta. A ruptured spleen can cause death. Call your doctor right away if you have pain in the left upper stomach area or left shoulder tip area. This pain could mean your spleen is enlarged or ruptured.
  • A serious lung problem called acute respiratory distress syndrome (ARDS). Call your health care provider or get emergency medical help right away if you get any of these symptoms of ARDS: fever, shortness of breath, trouble breathing, or a fast rate of breathing.
  • Serious Allergic Reactions. Get emergency medical help right away if you get any of these symptoms of a serious allergic reaction with Neulasta: shortness of breath, wheezing, dizziness, swelling around the mouth or eyes, fast pulse, sweating, and hives. If you have an allergic reaction during the delivery of Neulasta, remove the On-body Injector for Neulasta by grabbing the edge of the adhesive pad and peeling off the On-body Injector for Neulasta. Get emergency medical help right away.
  • Sickle Cell Crises. Severe sickle cell crises, and sometimes death, can happen in people with sickle cell trait or disease who receive filgrastim, a medicine similar to Neulasta.

The most common side effect of Neulasta is pain in the bones and in your arms and legs.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Neulasta. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

For more information about Neulasta, talk with your healthcare provider or pharmacist; go to, or call 1-844-696-3852 (1-844-MYNEULASTA).

Please see the Neulasta Patient Information for additional information.


Neulasta® (pegfilgrastim) is a prescription medication used to help reduce the chance of infection due to a low white blood cell count, in people with certain types of cancer (non-myeloid), who receive anti-cancer medicines (chemotherapy) that can cause fever and low blood cell count.

It is not known if Neulasta is safe and effective in children.

Help Paying for Neulasta®

There are programs available to help you pay for Neulasta®:

  • Neulasta FIRST STEP® Co-Pay Coupon Program—helps eligible patients limit the out-of-pocket cost of Neulasta®.
  • Amgen Assist® —helps connect patients with independent foundations that may assist with out-of-pocket costs

Neulasta FIRST STEP® Co-Pay Coupon Program

The Neulasta FIRST STEP® Program is a Co-Pay Coupon program that can help eligible patients meet their Neulasta® deductible, co-insurance, and/or co-payment (out-of-pocket) requirement.

Log on to or call 1-888-657-8371 for a complete list of eligibility requirements and program restrictions.

Neulasta FIRST STEP® Co-Pay
Coupon Program helps limit your
Neulasta® out-of-pocket
cost based on eligibility

Amgen Assist®

In addition to the programs that Amgen sponsors, Amgen makes donations to independent nonprofit co-pay patient assistance foundations that in turn give grants to assist qualifying insured patients who need help with out-of-pocket costs for medicines manufactured from across all of the industry. Such foundations make patient grant decisions based upon their own criteria and Amgen has no influence over such decisions. Patients who are insured (through private or government programs) but need financial assistance can be referred to these independent foundations for help.

Patients with commercial or government insurance (including Medicare) who need additional financial assistance can contact independent co-payment foundations, or Amgen Assist can refer patients to independent nonprofit co-payment foundations. Since these co-payment foundations are independent and not affiliated with Amgen, Amgen Assist® cannot guarantee that a patient will receive assistance. Each foundation has its own eligibility criteria, which include an evaluation of each individual’s financial, medical, and insurance status.

For more information about co-pay support, or to get contact information for independent co-pay foundations, or for a referral to an independent co-pay foundation, contact an Amgen Assist® service specialist at 1-888-4ASSIST (1-888-427-7478).


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