Indication

Neulasta® is a prescription medication used to help reduce the chance of infection due to a low white blood cell count, in people with certain types of cancer (non-myeloid), who receive anti-cancer medicines (chemotherapy) that can cause fever and low blood cell count.

Neulasta® is a prescription medication used to help reduce the chance of infection due to a low white blood cell count, in people with certain types of cancer (non-myeloid), who receive anti-cancer Read more medicines (chemotherapy) that can cause fever and low blood cell count. Close

Neulasta® is a prescription medication used to help reduce the chance of infection due to a low white blood cell count, Read more in people with certain types of cancer (non-myeloid), who receive anti-cancer medicines (chemotherapy) that can cause fever and low blood cell count. Close

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Infection and Chemotherapy

Learn how strong chemotherapy could increase your risk of infection

Chemotherapy is one of many treatments used to fight cancer, so if your doctor suggests chemotherapy for you, it can be helpful to understand how it works.

Chemotherapy works by killing the fast-growing cancer cells in your body. At the same time, chemotherapy can also decrease the number of white blood cells in your body. White blood cells are needed to fight infections. Having a low white blood cell count can weaken your immune system, which increases your risk of infection during your chemotherapy treatment.

Neulasta® reduced infection
risk by 94%

In a key study of 928 patients with breast cancer, when given once every chemotherapy cycle, Neulasta® reduced the risk of infection from 17% to 1%–a 94% decrease.

Learn more

Certain risk factors increase your chance of infection

According to national guidelines, if you are treated with strong chemotherapy, you may have a greater chance of developing low white blood cell counts or infections if any of the following conditions apply to you:

  • You are 65 or older.
  • You previously developed a low white blood cell count while being treated with strong chemo.
  • You already have a low white blood cell count while being treated with strong chemo.
  • Your cancer has spread to your bone marrow.
  • You've had strong chemotherapy or radiation before.
  • You have medical conditions like diabetes or liver or heart diseases.

Your doctor may recommend that you take a prescription medication that boosts the number of infection-fighting white blood cells called neutrophils.

What Can Happen to White Blood Cells During Strong Chemotherapy

Before chemotherapy

Before chemotherapy:

White blood cells are a key part of your immune system. At natural levels, white blood cells help protect your body against infection.

With strong chemotherapy

With strong chemotherapy:

Strong chemotherapy can lower the number of infection-fighting white blood cells in your body, which may weaken your immune system and increase your risk for certain types of infection.

Talk to your doctor about Neulasta® before starting strong chemo

Ask these questions

The importance of monitoring white blood cell counts

It's important for your doctor to monitor your white blood cell count throughout your chemotherapy treatment. Having a low white blood cell count increases your risk of developing certain types of infection. Your doctor may routinely use a test called a complete blood count (a CBC) before and during your chemotherapy treatment. A CBC can help tell if a patient is at increased risk of or has an infection.

Using medications to help boost your white blood cell count

It's important for your doctor to monitor all your blood counts throughout your chemotherapy treatment. If any fall below your normal range, your doctor may recommend certain prescription medicines.

Medications which may be called white blood cell boosters help your body produce more infection-fighting white blood cells during strong chemotherapy. These medications are man-made forms of a substance called granulocyte (gran-yoo-loh-site) colony-stimulating factor (G-CSF) that is naturally produced by the body. They stimulate the growth of a type of white blood cell called neutrophils, which are important in the body’s fight against infection.

Consider the possibility of fewer doctor visits with Neulasta® Onpro™*

* If, for any reason, you believe you did not receive your full dose of Neulasta® or that your On-body Injector is not working correctly, immediately contact your healthcare provider

Learn more

Important Safety Information

Who should not take Neulasta®?

Do not take Neulasta® if you have had a serious allergic reaction to Neulasta® (pegfilgrastim) or to NEUPOGEN® (filgrastim).

What should I tell my health care provider before taking Neulasta®? Tell your healthcare provider if you:

  • Have sickle cell trait or sickle cell disease
  • Have had severe skin reactions to acrylic adhesives
  • Are allergic to latex
  • Have problems with your kidneys
  • Have any other medical problems
  • Are pregnant or plan to become pregnant. It is not known if Neulasta® may harm your unborn baby.
  • Are breastfeeding or plan to breastfeed. It is not known if Neulasta® passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are possible serious side effects of Neulasta®?

  • Spleen Rupture. Your spleen may become enlarged and can rupture while taking Neulasta®. A ruptured spleen can cause death. Call your doctor right away if you have pain in the left upper stomach area or left shoulder tip area. This pain could mean your spleen is enlarged or ruptured.
  • A serious lung problem called Acute Respiratory Distress Syndrome (ARDS). Call your healthcare provider or get emergency medical help right away if you get any of these symptoms of ARDS: fever, shortness of breath, trouble breathing, or a fast rate of breathing.
  • Serious Allergic Reactions. Get emergency medical help right away if you get any of these symptoms of a serious allergic reaction with Neulasta®: shortness of breath, wheezing, dizziness, swelling around the mouth or eyes, fast pulse, sweating, and hives.

If you have an allergic reaction during the delivery of Neulasta®, remove the On-body Injector for Neulasta® by grabbing the edge of the adhesive pad and peeling off the On-body Injector. Get emergency medical help right away.

  • Sickle Cell Crises. Severe sickle cell crises, and sometimes death, can happen in people with sickle cell trait or disease who receive filgrastim, a medicine similar to Neulasta®.
  • Kidney injury (glomerulonephritis). Kidney injury has been seen in patients who received Neulasta®. You should notify your healthcare provider right away if you experience puffiness in your face or ankles, blood in your urine or brown colored urine or you notice you urinate less than usual.
  • Increased white blood cell count (leukocytosis). Your doctor will check your blood during treatment with Neulasta®.
  • Capillary Leak Syndrome. Neulasta® can cause fluid to leak from blood vessels into your body’s tissues. This condition is called "Capillary Leak Syndrome" (CLS). CLS can quickly cause you to have symptoms that may become life-threatening. Get emergency medical help right away if you develop any of the following symptoms:
    • swelling or puffiness and are urinating less often
    • trouble breathing
    • swelling of your stomach-area (abdomen) and feeling of fullness
    • dizziness or feeling faint
    • a general feeling of tiredness

The most common side effect of Neulasta® is pain in the bones and in your arms and legs.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Neulasta®. Call your doctor for medical advice about side effects. You may report negative side effects to the FDA at 1-800-FDA-1088.

For more information about Neulasta®, talk with your healthcare provider or pharmacist; go to www.neulasta.com, or call 1-844-696-3852 (1-844-MYNEULASTA).

Please see Neulasta® Patient Information.

Important Safety Information
Who should not take Neulasta®?
Do not take Neulasta® if you have had a serious allergic reaction to Neulasta® (pegfilgrastim) or to NEUPOGEN® (filgrastim).
What should I tell my health care provider before taking Neulasta®? Tell your healthcare provider if you:
• Have sickle cell trait or sickle cell disease

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